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Mutants (sensitive: M207; resistant: M244) and BRAF mutants (sensitive: M229 and M249; resistant: M233 and M263) were cultured with 50 nM and 500 nM of TAK733 for 48 hours and stained with DAPI for cell cycle analysis.Discussion Initial data testing MEK inhibitors in melanoma cell lines suggested a high level and selective sensitivity in BRAF V600E mutant melanoma cell lines, with low sensitivity
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Adache, vertigo, and vomiting. Ethanol induced an increase in the levels of norepinephrine in paternally exposed offspring. Serotonin levels were reduced in the cerebrum, and metenkephalin levels were increased in all brain regions of offspring from both maternally and paternally exposed rats [10]. Methyl tertiary butyl ether (MTBE) is an aliphatic ether, a volatile, colorless, and inflammable liq
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Nium Pharmaceuticals, Inc., the manufacturer of TAK733. Acknowledgements This work was funded by The Seaver Institute, the Melanoma Research Foundation, the Melanoma Research Alliance, the Louise Belley and Richard Schnarr Fund, the Wesley Coyle Memorial Fund, the Garcia-Corsini Family Fund, the Keiter Family Foundation and the Caltech-UCLA Joint Center for Translational Medicine (all to A.R.). Au
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