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F the cell viability assays.Euw et al. Molecular Cancer 2012, 11:22 http://www.molecular-cancer.com/content/11/1/Page 5 ofa)500 nM TAK733 50 nM TAK733 Ve l V hiceb)M249 (BRAF mutant, sensitive) ii )M233 (BRAF mutant, resistant) i )100 80c)60 40 20 0ol Contro 50nM 5 M 00nM 50 M ol Contro 50nM 5 M 00nM 50 M ol Contro 50nM 5 M 00nM 50 M ol Contro 50nM 5 M 00nM 50 M ol Contro 50nM 5 M 00nM 50 M
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F the cell viability assays.Euw et al. Molecular Cancer 2012, 11:22 http://www.molecular-cancer.com/content/11/1/Page 5 ofa)500 nM TAK733 50 nM TAK733 Ve l V hiceb)M249 (BRAF mutant, sensitive) ii )M233 (BRAF mutant, resistant) i )100 80c)60 40 20 0ol Contro 50nM 5 M 00nM 50 M ol Contro 50nM 5 M 00nM 50 M ol Contro 50nM 5 M 00nM 50 M ol Contro 50nM 5 M 00nM 50 M ol Contro 50nM 5 M 00nM 50 M
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Nium Pharmaceuticals, Inc., the manufacturer of TAK733. Acknowledgements This work was funded by The Seaver Institute, the Melanoma Research Foundation, the Melanoma Research Alliance, the Louise Belley and Richard Schnarr Fund, the Wesley Coyle Memorial Fund, the Garcia-Corsini Family Fund, the Keiter Family Foundation and the Caltech-UCLA Joint Center for Translational Medicine (all to A.R.). Au
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Er, a barometer, thermometer and hygrometer were installed in order to continuously register the pressure, temperature and humidity, respectively. The animals were kept in an inhalation chamber and the gasoline was evaporated in a vaporizer and the vapours passed through a rubber tube to the inhalation chamber. By calculating the amount of gasoline vapours was determined as part per million (ppm)