""Background? Lipohydroxyacid is a lipophilic derivative of salicylic acid with comedolytic properties. Objectives? To compare lipohydroxyacid and salicylic acid #links# peels in subjects with comedonal acne. Methods? In this split face, randomized study, 20 subjects with comedonal acne received lipohydroxyacid peels on one side of the face, while the other side was treated with salicylic acid pee