Dues of the RING domain (as well as the Zn++ ions) are required for proper foldingBinding Determinants of Rocsand function of the protein [7,9,15,16,17]. The importance to E3 ligase function of residues or domains outside of the RING domain is not currently understood. RING E3's can be further categorized as either single or multiprotein complexes. Single protein E3's, like c-Cbl, perform the enti
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