BookMarking Page - Y is consistent with the haploinsufficient effect of the gene observed http://bookmarkingpage.com/story.php?title=y-is-consistent-with-the-haploinsufficient-effect-of-the-gene-observed-79 Y is consistent with the haploinsufficient effect of the gene observed in our mouse KO model. Indeed, mice hetero- or homozygous on the Tusc2 deletion shared similar immunological and tumorigenic phenotypes at comparable frequencies. These data suggest that even partial loss of the TUSC2 dosage is sufficient to trigger pathological inflammation and increase susceptibility to cancer [15]. We consid Wed, 11 Jul 2018 21:21:54 UTC en