Mesothelioma remains incurable in 2024 due to its aggressive nature and late-stage detection. This rare cancer, primarily caused by asbestos exposure, develops in the linings of the lungs, abdomen, or heart. Early symptoms often mimic other illnesses, leading to delayed diagnosis. By the time mesothelioma is identified, it has usually spread extensively, making treatment options like surgery, chemotherapy, and radiation less effective. Additionally, mesothelioma cells are highly resistant to current therapies, and research for a definitive cure is ongoing. While treatments can extend life and improve quality, mesothelioma remains a fatal disease in most cases.